Serie A returns after a short break, and we take a closer look at three Round 6 fixtures taking place across Saturday, 10 October, and Sunday, 11 October, before suggesting a bet in each game.
Outright Betting Update
Inter remain strong favourites to retain the Serie A title at 1.65. AS Roma are next in the betting at 6.00, followed by AC Milan at 9.00, with the balance available at 11.00 and bigger.
Click here for the latest Serie A outright betting
Saturday
Napoli v Frosinone
Napoli are ninth in the standings with seven points after winning two, drawing one and losing two of their opening five matches. They have scored seven goals and conceded six.
Their latest match ended in a 1-1 draw away to Fiorentina. Before that, they beat Bologna 1-0 at home, lost 3-2 away to Inter and suffered a 2-1 home defeat to Como. Napoli opened their campaign with a 2-0 victory away to Genoa.
Frosinone are sixth with 10 points after recording three victories, one draw and one defeat. They have scored nine goals and conceded four.
Their only defeat came in the opening round, when they lost 1-0 at home to Juventus. Frosinone have since beaten Fiorentina 3-0 away, Venezia 3-2 at home and Como 2-0 at home, while their trip to Genoa ended in a 1-1 draw.
Head-to-Head
Napoli have won three of the last five meetings between the sides across all competitions. Frosinone have won once, with the other match ending in a draw.
Betting – Click here to bet
Napoli 1.44
Draw 5.25
Frosinone 6.75
Verdict
Napoli have scored in all five of their league matches this season, but they have kept only two clean sheets. Frosinone have made an excellent start and have scored nine goals, finding the net in four of their five games. Napoli’s home advantage can help them secure the points, but the visitors have shown enough going forward to contribute to the scoring.
BET: Match Result and Both Teams to Score – Napoli and Yes at 2.75
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Sunday
Como v AS Roma
Como are eighth with 10 points after winning three, drawing one and losing one of their opening five matches. They have scored nine goals and conceded six.
They opened with a 1-1 draw away to Udinese before recording three consecutive victories: 2-1 away to Napoli, 2-1 at home to Parma and 4-1 away to Genoa. Como’s winning run ended with a 2-0 defeat at Frosinone in their most recent outing.
AS Roma have made an excellent start, winning four of their first five Serie A matches and drawing the other. They lead the standings with 13 points, having scored 14 goals and conceded only three.
Roma began with a 4-0 home victory over Fiorentina before recording another 4-0 win away to Lecce. They then beat Atalanta 2-1 at home and Torino 2-0 away, before being held to a 2-2 home draw by Inter last time out.
Head-to-Head
The teams have each won three of their last six meetings, with none of those matches ending in a draw.
Betting – Click here to bet
Como 2.60
Draw 3.65
AS Roma 2.70
Verdict
Roma are unbeaten and have been the more convincing of the two sides, scoring 14 goals while conceding only three. Como have nevertheless won three of their opening five matches and should benefit from home advantage. Rather than taking the visitors in the outright market, Roma draw no bet offers some protection if this evenly priced contest finishes level.
BET: AS Roma Draw No Bet at 1.93
Cagliari v Juventus
Cagliari are fourth with 12 points after winning four and losing one of their opening five matches. They have scored five goals and conceded only two.
Their only defeat came against Inter, who beat them 1-0 in the second round. Cagliari responded with three consecutive victories, beating Lecce 1-0 at home before winning 2-1 away to Atalanta and 1-0 away to Udinese.
Juventus are seventh with 10 points after winning three, drawing one and losing one of their five matches. They have scored eight goals and conceded four.
Juventus come into this match following a 2-0 home victory over Atalanta. Before that, they lost 3-2 away to Sassuolo and drew 1-1 at home to AC Milan.
Head-to-Head
Juventus have won three of the last six meetings between the sides across all competitions. Cagliari have won once, while the other two matches ended in draws. Those Juventus victories include a 4-0 Coppa Italia success in the 2024/25 season, although Cagliari won the most recent encounter 1-0 in January 2026.
Betting – Click here to bet
Cagliari 6.50
Draw 4.00
Juventus 1.59
Verdict
Juventus are understandably strong favourites and responded well to their defeat at Sassuolo by beating Atalanta 2-0. Cagliari have made an excellent start, but their success has been built on a disciplined defence rather than prolific scoring, with only five goals in five matches. Juventus have already recorded two league victories without conceding and can use their greater quality to edge another tight contest while keeping Cagliari off the scoresheet.
BET: Match Result and Both Teams to Score – Juventus and No at 2.50
Note: All prices are correct at the time of writing but are subject to change.
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